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Journal Articles EMBO Molecular Medicine Year : 2021

Immunodynamics of explanted human tumors for immuno-oncology

Vincent Thomas de Montpreville
Camélia Radulescu
  • Function : Author
Sophie Ferlicot
  • Function : Author
David J. Figueroa
  • Function : Author
Sapna Yadavilli
  • Function : Author
Jeremy D. Waight
  • Function : Author
Marc S. Ballas
  • Function : Author
Axel X. Hoos
  • Function : Author
Thomas Condamine
  • Function : Author
Bastien Parier
  • Function : Author
Ingrid Breuskin
  • Function : Author
Cédric Lebacle
  • Function : Author
Hervé Baumert
  • Function : Author
Élie Fadel
  • Function : Author

Abstract

Decision making in immuno-oncology is pivotal to adapt therapy to the tumor microenvironment (TME) of the patient among the numerous options of monoclonal antibodies or small molecules. Predicting the best combinatorial regimen remains an unmet medical need. Here, we report a multiplex functional and dynamic immuno-assay based on the capacity of the TME to respond to ex vivo stimulation with twelve immunomodulators including immune checkpoint inhibitors (ICI) in 43 human primary tumors. This "in sitro" (in situ/in vitro) assay has the potential to predict unresponsiveness to anti-PD-1 mAbs, and to detect the most appropriate and personalized combinatorial regimen. Prospective clinical trials are awaited to validate this in sitro assay.
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Dates and versions

hal-03127487 , version 1 (02-06-2022)

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Agathe Dubuisson, Jean Eudes Fahrner, Anne Gaëlle Goubet, Safae A. Terrisse, Nicolas Voisin, et al.. Immunodynamics of explanted human tumors for immuno-oncology. EMBO Molecular Medicine, 2021, 13 (1), ⟨10.15252/emmm.202012850⟩. ⟨hal-03127487⟩
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